Researchers showed that small engineered proteins can restore the function of mutated p53 by stabilizing its structure. The ...

Scientists from a German-Swiss consortium have developed miniature antibody-like proteins, called DARPins, that can stabilize and reactivate multiple mutated forms of the p53 tumor suppressor protein ...

Each year, 20 million people are diagnosed with cancer. Various organs can be affected, and cancer types sometimes differ ...

This review illustrates how the nuclear phosphoinositide-p53 signalosome integrates lipid signaling and p53 function to regulate cancer cell motility. The figure contrasts the tumor-suppressive ...

The tumor suppressor protein p53 plays a critical role in preventing cancer by regulating cell cycle, apoptosis, and genomic stability. However, mutations in the P53 gene are found in over 50% of ...

The p53 gene plays an important role in cell biology as it regulates the cell cycle and halts the formation of tumors. While the gene was discovered more than four decades ago, researchers are still ...

(TP53), widely known as the “guardian of the genome,” is one of the most frequently altered genes in human cancer. While its canonical tumor-suppressive ...

In the 1970s, scientists knew that some viruses and chemicals caused cancer, but they didn’t know how. Arnold Levine, a biologist currently at the Institute for Advanced Study researched DNA viruses ...

Treatment of patients with dedifferentiated liposarcoma (DDLPS) with the MDM2–p53 antagonist brigimadlin and p53 function: A longitudinal analysis of circulating microRNAs (miRNAs) in a first-in-human ...

Each year, 20 million people are diagnosed with cancer. Various organs can be affected, and cancer types sometimes differ greatly at the cellular and ...